Computational Biology of Olfactory Receptors
نویسندگان
چکیده
منابع مشابه
Computational Biology of Olfactory Receptors.
Olfactory receptors, in addition to being involved in first step of the physiological processes that leads to olfaction, occupy an important place in mammalian genomes. ORs constitute super families in these genomes. Elucidating ol-factory receptor function at a molecular level can be aided by a computationally derived structure and an understanding of its interactions with odor molecules. Expe...
متن کاملMolecular biology of olfactory receptors.
OR proteins bind odorant ligands and transmit a G-protein-mediated intracellular signal, resulting in generation of an action potential. The accumulation of DNA sequences of hundreds of OR genes provides an opportunity to predict features related to their structure, function and evolutionary diversification. The OR repertoire has evolved a variable ligand-binding site that ascertains recognitio...
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متن کاملOlfactory Receptors, Vomeronasal Receptors, and the Organization of Olfactory Information
observed with a variety of molecular markers. For examThe main olfactory system of mammals recognizes the ple, the Ga protein Gi2 is expressed at high levels only universe of odorants using as many as a thousand rein apical neurons, while the Ga protein Go is expressed lated G protein–coupled receptors (Buck and Axel, at high levels only in basal neurons (Halpern et al., 1995; 1991). Oddly enou...
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In many species, the sense of smell plays important roles in locating food, detecting predators, navigating, and communicating social information. The olfactory system has evolved complex repertoires of odor receptors (ORs) to fulfill these functions. Through computational data mining, OR repertoires of multiple species were identified, revealing a surprisingly large OR gene family in rodents a...
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ژورنال
عنوان ژورنال: Current Bioinformatics
سال: 2009
ISSN: 1574-8936
DOI: 10.2174/157489309787158143